Magnetic nanoparticles based cancer therapy: current status and applications

Sci China Life Sci. 2018 Apr;61(4):400-414. doi: 10.1007/s11427-017-9271-1. Epub 2018 Apr 3.

Abstract

Nanotechnology holds a promising potential for developing biomedical nanoplatforms in cancer therapy. The magnetic nanoparticles, which integrate uniquely appealing features of magnetic manipulation, nanoscale heat generator, localized magnetic field and enzyme-mimics, prompt the development and application of magnetic nanoparticles-based cancer medicine. Considerable success has been achieved in improving the magnetic resonance imaging (MRI) sensitivity, and the therapeutic function of the magnetic nanoparticles should be given adequate attention. This work reviews the current status and applications of magnetic nanoparticles based cancer therapy. The advantages of magnetic nanoparticles that may contribute to improved therapeutics efficacy of clinic cancer treatment are highlighted here.

Keywords: magnetic hyperthermia treatment; magnetic nanoparticles; theranostics; therapeutic delivery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use*
  • Drug Carriers / chemistry
  • Drug Carriers / therapeutic use
  • Drug Delivery Systems* / trends
  • Humans
  • Magnetic Resonance Imaging
  • Magnetite Nanoparticles / chemistry
  • Magnetite Nanoparticles / therapeutic use*
  • Neoplasms / diagnosis
  • Neoplasms / therapy*
  • Theranostic Nanomedicine

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Magnetite Nanoparticles