Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye

Matthias Salas; Marco Augustin; Franz Felberer; Andreas Wartak; Marie Laslandes; Laurin Ginner; Michael Niederleithner; Jason Ensher; Michael P Minneman; Rainer A Leitgeb; Wolfgang Drexler; Xavier Levecq; Ursula Schmidt-Erfurth; Michael Pircher

doi:10.1364/BOE.9.001871

Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye

Biomed Opt Express. 2018 Mar 26;9(4):1871-1892. doi: 10.1364/BOE.9.001871. eCollection 2018 Apr 1.

Authors

Matthias Salas^{1

2}, Marco Augustin¹, Franz Felberer³, Andreas Wartak¹, Marie Laslandes¹, Laurin Ginner^{1

2}, Michael Niederleithner¹, Jason Ensher⁴, Michael P Minneman⁴, Rainer A Leitgeb^{1

2}, Wolfgang Drexler¹, Xavier Levecq³, Ursula Schmidt-Erfurth⁵, Michael Pircher¹

Affiliations

¹ Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
² Christian Doppler Laboratory for Innovative Optical Imaging and Its Translation to Medicine, Medical University of Vienna, Vienna, Austria.
³ Imagine Eyes, Orsay, France.
⁴ INSIGHT Photonic Solutions, Inc., Lafayette, CO, USA.
⁵ Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.

Abstract

Imaging of the human retina with high resolution is an essential step towards improved diagnosis and treatment control. In this paper, we introduce a compact, clinically user-friendly instrument based on swept source optical coherence tomography (SS-OCT). A key feature of the system is the realization of two different operation modes. The first operation mode is similar to conventional OCT imaging and provides large field of view (FoV) images (up to 45° × 30°) of the human retina and choroid with standard resolution. The second operation mode enables it to optically zoom into regions of interest with high transverse resolution using adaptive optics (AO). The FoV of this second operation mode (AO-OCT mode) is 3.0° × 2.8° and enables the visualization of individual retinal cells such as cone photoreceptors or choriocapillaris. The OCT engine is based on an akinetic swept source at 1060 nm and provides an A-scan rate of 200 kHz. Structural as well as angiographic information can be retrieved from the retina and choroid in both operational modes. The capabilities of the prototype are demonstrated in healthy and diseased eyes.

Keywords: (110.1080) Active or adaptive optics; (110.4500) Optical coherence tomography; (170.3890) Medical optics instrumentation; (170.4470) Ophthalmology.