Direct ion generation from swabs

Alan K Jarmusch; Valentina Pirro; David L Logsdon; R Graham Cooks

doi:10.1016/j.talanta.2018.02.105

Direct ion generation from swabs

Talanta. 2018 Jul 1:184:356-363. doi: 10.1016/j.talanta.2018.02.105. Epub 2018 Mar 12.

Authors

Alan K Jarmusch¹, Valentina Pirro¹, David L Logsdon¹, R Graham Cooks²

Affiliations

¹ Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907, United States.
² Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907, United States. Electronic address: cooks@purdue.edu.

PMID: 29674054
DOI: 10.1016/j.talanta.2018.02.105

Abstract

Medical swabs are used for biofluid and tissue sampling in clinical applications. The use of medical swabs as electrospray ionization probes for direct mass spectrometric analysis is a novel and potentially widely applicable development. Here we discuss ion generation, characterize ionization behavior via microscopic videography and describe some illustrative examples of applications.

Keywords: Ambient ionization; Electrospray; In vivo sampling; Mass spectrometry; Medical swabs; Point-of-care testing.

MeSH terms

Spectrometry, Mass, Electrospray Ionization / instrumentation*