Brain Imaging Using Hyperpolarized 129Xe Magnetic Resonance Imaging

Methods Enzymol. 2018:603:305-320. doi: 10.1016/bs.mie.2018.01.027. Epub 2018 Mar 23.

Abstract

Hyperpolarized (HP) 129Xe magnetic resonance imaging (MRI) is a novel iteration of traditional MRI that relies on detecting the spins of 1H. Since 129Xe is a gaseous signal source, it can be used for lung imaging. Additionally, 129Xe dissolves in the blood stream and can therefore be detectable in the brain parenchyma and vasculature. In this work, we provide detailed information on the protocols that we have developed to image 129Xe within the brains of both rodents and human subjects.

Keywords: Brain imaging; Brain mapping; Hyperpolarization; Magnetic resonance imaging; Xenon.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthesia, General / methods*
  • Anesthetics, Inhalation*
  • Anesthetics, Intravenous*
  • Animals
  • Brain / diagnostic imaging*
  • Brain / physiology
  • Drug Dosage Calculations
  • Functional Neuroimaging / instrumentation
  • Functional Neuroimaging / methods*
  • Humans
  • Intubation, Intratracheal / methods
  • Isoflurane
  • Magnetic Resonance Imaging / instrumentation
  • Magnetic Resonance Imaging / methods*
  • Propofol
  • Rats
  • Respiration, Artificial / methods
  • Xenon Isotopes / administration & dosage

Substances

  • Anesthetics, Inhalation
  • Anesthetics, Intravenous
  • Xenon Isotopes
  • Xenon-129
  • Isoflurane
  • Propofol

Grants and funding