Cholesterol, cancer, and rebooting a treatment for athlete's foot

Ngee Kiat Chua; Hudson W Coates; Andrew J Brown

doi:10.1126/scitranslmed.aat3741

Cholesterol, cancer, and rebooting a treatment for athlete's foot

Sci Transl Med. 2018 Apr 18;10(437):eaat3741. doi: 10.1126/scitranslmed.aat3741.

Authors

Ngee Kiat Chua¹, Hudson W Coates¹, Andrew J Brown²

Affiliations

¹ School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
² School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia. aj.brown@unsw.edu.au.

PMID: 29669852
DOI: 10.1126/scitranslmed.aat3741

Abstract

A key enzyme in cholesterol synthesis is placed firmly on the oncogenic map and demonstrated to be a potential therapeutic target in liver cancer by repurposing a common antifungal agent (Liu et al, this issue).

Publication types

Review

MeSH terms

Animals
Antifungal Agents / therapeutic use
Cholesterol / metabolism
Drug Repositioning / methods
Humans
Liver Neoplasms / metabolism
Neoplasms / metabolism*
Oxidative Stress / physiology
Tinea Pedis / metabolism*

Substances

Antifungal Agents
Cholesterol