In the last decade, transition-metal catalyzed C-H functionalization reactions have progressed enormously, becoming a useful tool in organic synthesis and a practical alternative to well-established methodologies. Very recently, research efforts have also been devoted to developing more sustainable C-H functionalization protocols, in order to increase their applicability. One of the most promising approaches in this sense is represented by the substitution of common reaction media with bio-based solvents. In the present contribution a general perspective on the benefits of this approach is given, followed by key literature examples.
Keywords: C−H functionalization; biomass; catalysis; green chemistry; renewable resources.
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