Hepatocellular carcinoma: Prospects for natural killer cell immunotherapy

N Kumar; S I Khakoo

doi:10.1111/tan.13275

Hepatocellular carcinoma: Prospects for natural killer cell immunotherapy

HLA. 2018 Apr 17. doi: 10.1111/tan.13275. Online ahead of print.

Authors

N Kumar¹, S I Khakoo²

Affiliations

¹ Section of Hepatology, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
² Department of Clinical and Experimental Sciences, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK.

PMID: 29667374
DOI: 10.1111/tan.13275

Abstract

Liver disease is a growing cause of death in the United Kingdom and the incidence of hepatocellular carcinoma (HCC) is rising (http://www.cancerresearchuk.org/). The combination of an immunosuppressive environment within the liver and suboptimal host anti-tumour immune responses may account for the poor survival outcome of HCC. Understanding how tumours evade immune recognition coupled with new insights into the unique immunological environment within the liver will be critical to developing liver-specific immunotherapies.

Keywords: adoptive transfer; cancer; hepatocellular carcinoma; immunotherapy; natural killer cells.

Publication types

Review

Abstract

Publication types

Grants and funding