The role of high-mobility group protein box 1 in lung cancer

J Cell Biochem. 2018 Aug;119(8):6354-6365. doi: 10.1002/jcb.26837. Epub 2018 Apr 17.

Abstract

High-mobility group protein box 1(HMGB1)is a ubiquitous highly conserved nuclear protein. Acting as a chromatin-binding factor, HMGB1 binds to DNA and plays an important role in stabilizing nucleosome formation, facilitating gene transcription, DNA repairing, inflammation, cell differentiation, and regulating the activity of steroid hormone receptors. Currently, HMGB1 is discovered to be related to development, progression, and targeted therapy of lung cancer, which makes it an attractive biomarker, and therapeutic target. This review aims to encapsulate the relationship between HMGB1 and lung cancer, suggesting that HMGB1 plays a pivotal role in initiation, development, invasion, metastasis, and prognosis of lung cancer.

Keywords: RAGE; TLRs; high-mobility group protein box 1 (HMGB1); lung cancer; metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism*
  • DNA, Neoplasm / genetics
  • DNA, Neoplasm / metabolism
  • HMGB1 Protein / genetics
  • HMGB1 Protein / metabolism*
  • Humans
  • Lung Neoplasms / genetics
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / pathology
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Nucleosomes / genetics
  • Nucleosomes / metabolism
  • Nucleosomes / pathology

Substances

  • Biomarkers, Tumor
  • DNA, Neoplasm
  • HMGB1 Protein
  • HMGB1 protein, human
  • Neoplasm Proteins
  • Nucleosomes