Chikungunya virus causes fever and severe polyarthritis or arthralgia and is associated with neurologic manifestations that are sometimes challenging to diagnose. We demonstrate intrathecal synthesis of chikungunya antibodies in a patient with a history of acute infection complicated by encephalitis. The specificity of the intracerebral immune response supports early chikungunya-associated encephalitis diagnosis.
Keywords: CHIKV; IgG; IgM; alphavirus; cerebrospinal fluid; chikungunya virus; humoral immune response; immunoglobulins; meningitis/encephalitis; vector-borne infections; viruses.