Abstract
Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.
MeSH terms
-
Adenine / chemistry
-
Adenine / metabolism*
-
Adenine / toxicity
-
Alanine / chemistry
-
Anisotropy
-
Diphenylhexatriene / analogs & derivatives
-
Diphenylhexatriene / chemistry
-
Fluorescence
-
HEK293 Cells
-
Humans
-
Hydrogen Bonding
-
Lipid Bilayers / chemistry
-
Lipid Bilayers / metabolism*
-
Macromolecular Substances / chemistry
-
Macromolecular Substances / metabolism*
-
Macromolecular Substances / toxicity
-
Molecular Dynamics Simulation
-
Phosphatidylcholines / chemistry
-
Phosphatidylcholines / metabolism
-
Phosphatidylserines / chemistry
-
Phosphatidylserines / metabolism
-
Polyacetylene Polymer
-
Polymers / chemistry
-
Polymers / metabolism
-
Polyynes / chemistry
-
Polyynes / metabolism
-
Tryptophan / chemistry
-
Tryptophan / metabolism*
-
Tryptophan / toxicity
-
Tyrosine / chemistry
-
Tyrosine / metabolism*
-
Tyrosine / toxicity
Substances
-
Lipid Bilayers
-
Macromolecular Substances
-
Phosphatidylcholines
-
Phosphatidylserines
-
Polyacetylene Polymer
-
Polymers
-
Diphenylhexatriene
-
Polyynes
-
polydiacetylene
-
Tyrosine
-
1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene
-
Tryptophan
-
Adenine
-
Alanine