Body mass index, sitting time, and risk of Parkinson disease

Elin Roos; Alessandra Grotta; Fei Yang; Rino Bellocco; Weimin Ye; Hans-Olov Adami; Karin Wirdefeldt; Ylva Trolle Lagerros

doi:10.1212/WNL.0000000000005328

Body mass index, sitting time, and risk of Parkinson disease

Neurology. 2018 Apr 17;90(16):e1413-e1417. doi: 10.1212/WNL.0000000000005328. Epub 2018 Mar 21.

Authors

Elin Roos¹, Alessandra Grotta¹, Fei Yang¹, Rino Bellocco¹, Weimin Ye¹, Hans-Olov Adami¹, Karin Wirdefeldt¹, Ylva Trolle Lagerros²

Affiliations

¹ From the Department of Medicine (E.R., Y.T.L.), Unit of Clinical Epidemiology, Karolinska Institutet, T2, Stockholm; Department of Medical Epidemiology and Biostatistics (A.G., F.Y., R.B., W.Y., H.-O.A., K.W.), and Department of Clinical Neuroscience (K.W.), Karolinska Institutet, Stockholm; Centre for Health Equity Studies (A.G.), Stockholm University/Karolinska Institutet, Stockholm, Sweden; Department of Statistics and Quantitative Methods (R.B.), University of Milano-Bicocca, Milan, Italy; Clinical Effectiveness Research Group (H.-O.A.), Institute of Health and Society, University of Oslo, Norway; and Department of Medicine (Y.T.L.), Clinic of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.
² From the Department of Medicine (E.R., Y.T.L.), Unit of Clinical Epidemiology, Karolinska Institutet, T2, Stockholm; Department of Medical Epidemiology and Biostatistics (A.G., F.Y., R.B., W.Y., H.-O.A., K.W.), and Department of Clinical Neuroscience (K.W.), Karolinska Institutet, Stockholm; Centre for Health Equity Studies (A.G.), Stockholm University/Karolinska Institutet, Stockholm, Sweden; Department of Statistics and Quantitative Methods (R.B.), University of Milano-Bicocca, Milan, Italy; Clinical Effectiveness Research Group (H.-O.A.), Institute of Health and Society, University of Oslo, Norway; and Department of Medicine (Y.T.L.), Clinic of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden. ylva.trolle@ki.se.

Abstract

Objective: Causes of Parkinson disease are largely unknown, but recent evidence suggests associations with physical activity and anthropometric measures.

Methods: We prospectively analyzed a cohort of 41,638 Swedish men and women by detailed assessment of lifestyle factors at baseline in 1997. Complete follow-up until 2010 was achieved through linkage to population-based registers. We used multivariable Cox proportional hazards models to estimate hazard ratios with 95% confidence intervals (CIs).

Results: We identified 286 incident cases of Parkinson disease during follow-up. Multivariable adjusted hazard ratios were 1.06 (95% CI 0.76-1.47) for sitting time ≥6 vs <6 hours per day; and 1.13 (95% CI 0.60-2.12) for body mass index ≥30 vs <25 kg/m². Results did not differ by sex.

Conclusions: No association between prolonged sitting time per day or obesity and risk of Parkinson disease was found.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Body Mass Index*
Cohort Studies
Exercise
Female
Humans
Life Style
Male
Middle Aged
Parkinson Disease / epidemiology*
Parkinson Disease / physiopathology*
Proportional Hazards Models
Risk Factors
Sitting Position*
Sweden