Submonomer Strategy toward Divergent Solid-Phase Synthesis of α-ABpeptoids

Ganesh A Sable; Kang Ju Lee; Min-Kyung Shin; Hyun-Suk Lim

doi:10.1021/acs.orglett.8b00661

Submonomer Strategy toward Divergent Solid-Phase Synthesis of α-ABpeptoids

Org Lett. 2018 May 4;20(9):2526-2529. doi: 10.1021/acs.orglett.8b00661. Epub 2018 Apr 16.

Authors

Ganesh A Sable¹, Kang Ju Lee¹, Min-Kyung Shin¹, Hyun-Suk Lim¹

Affiliation

¹ Department of Chemistry and Division of Advanced Material Science , Pohang University of Science and Technology (POSTECH) , Pohang 37673 , South Korea.

PMID: 29659283
DOI: 10.1021/acs.orglett.8b00661

Abstract

A novel submonomer solid-phase synthetic method for α-ABpeptoid oligomers is reported. Iterative submonomer coupling and Fukuyama-Mitsunobu alkylation enable facile, divergent synthesis of α-ABpeptoid oligomers substituted with chemically diverse side chains in excellent yields.

Publication types

Research Support, Non-U.S. Gov't