[Dynamic changes of reproductive hormone levels and related factors in old and middleaged men in health examination]

Zhonghua Nan Ke Xue. 2017 Feb;23(2):131-136.
[Article in Chinese]

Abstract
in English, Chinese

Objective: To investigate the dynamic changes of serum reproductive hormone levels in old and middleaged males in health examination and their correlation with age and lipid profile.

Methods: This study included 4 333 men in health examination from January 2011 to December 2014. The men were aged from 40 to 85 years old and divided into seven fiveyearspan age groups. We determined the levels of serum testosterone (T), luteinizing hormone (LH), folliclestimulating hormone (FSH), estradiol (E2), progesterone (P), prolactin (PRL), total cholesterol (TC), triglyceride (TG), lowdensity lipoprotein cholesterol (LDLC), highdensity lipoprotein cholesterol (HDLC), and the testosterone secretion index (TSI = T/LH). We analyzed the obtained data using SPSS Pram, KruskalWallis H test, MannWhitney U test, exponential regression, and Spearman correlation analysis.

Results: Statistically significant differences were found in LH, FSH, E2 and TSI among the seven age groups (P< 0.05). The levels of serum LH, FSH and E2 were significantly higher (P< 0.05) while TSI remarkably lower (P< 0.05) in the ≥70 yr group than in the other six groups. The serum T and E2 levels and TSI were markedly lower in the 40－44, 45－49 and 50－54 yr groups in 2014 than in the other three years (P< 0.05), and so were the levels of serum T and TSI in the 55－59 yr group (P< 0.05). The levels of serum LH, FSH and E2 were correlated positively while those of P, PRL and TSI negatively with age. The serum T level was correlated positively with HDLC but negatively with TC, TG and LDLC. The levels of serum LH, FSH and E2 showed a yearly average increase of 1.9%, 2.7% and 0.5%, respectively, while TSI an annual mean decline of 2.0% in the 40－85 yr group.

Conclusions: LH, FSH and E2 were increased while TSI decreased with age in the >40 years old males. T and TSI were reduced in the 40－59 years old men from 2011 to 2014, and so was E2 in the 40－54 yr group. Lowlevel testosterone is closely related to dyslipidemia.

目的： 调查中老年男性体检人群生殖激素水平的动态变化及与年龄、血脂的关系。方法： 2011年1月至2014年12月40岁以上正常健康体检男性4 333例，年龄40~85岁，70岁以下者按5年间隔分组，70岁以上者为1组，共分为7组。测定血清睾酮（T）、黄体生成素（LH）、卵泡刺激素（FSH）、雌二醇（E2）、孕酮（P）、催乳素（PRL）和总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDLC）、高密度脂蛋白胆固醇（HDLC），并计算睾酮分泌指数（TSI=T/LH）。 结果： 7个年龄组的LH、FSH、E2和TSI水平有显著性差异（P均< 0.05）。≥70岁组的LH、FSH和E2水平显著高于其他6个年龄组（P均< 0.05），而TSI水平显著低于其他6组（P均< 0.05）。2014年40~44岁组、45~49岁组及50~54岁组的T、E2和TSI水平均显著低于其他3个年份的相应年龄组（P均< 0.05）；2014年55~59岁组的T和TSI水平显著低于其他3个年份（P均< 0.05）。LH、FSH和E2与年龄呈正相关，P、PRL和TSI与年龄呈负相关；T与TC、TG、LDLC呈负相关，与HDLC呈正相关。40～85岁男性LH、FSH和E2的平均年增长率分别为1.9%、2.7%和0.5%，TSI平均年下降率为2.0%。 结论： 40岁以上男性LH、FSH和E2随年龄增长而升高，TSI逐渐减低；40~59岁男性T和TSI 4年间有下降趋势，40~54岁男性E2 4年间有下降趋势；低水平T与血脂异常有着密切关系。.

Keywords: age; male; reproductive hormone; serum lipid.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / blood*
  • Estradiol / blood*
  • Follicle Stimulating Hormone / blood*
  • Humans
  • Lipids / blood*
  • Luteinizing Hormone / blood*
  • Male
  • Middle Aged
  • Progesterone / blood*
  • Prolactin / blood*
  • Reproduction
  • Statistics, Nonparametric
  • Testosterone / blood*

Substances

  • Lipids
  • Testosterone
  • Progesterone
  • Estradiol
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone