[Vasectomy has no obvious longterm influence on the levels of serum androgens in aging males]

Zhonghua Nan Ke Xue. 2017 Feb;23(2):125-130.
[Article in Chinese]

Abstract
in English, Chinese

Objective: To explore the longterm influence of vasectomy on the levels of serum androgens in aging males.

Methods: Using stratified random sampling, we conducted a questionnaire survey and physical examinations among 437 adult males aged ≥40 years, 232 with and 205 without the history of vasectomy. In addition, we measured the levels of serum total testosterone (TT), sexhormone binding globulin (SHBG), calculated free testosterone (cFT), testosterone secreting index (TSI), free testosterone index (FTI), and luteinizing hormone (LH).

Results: Compared with the nonvasectomy group, the vasectomy group showed significantly increased levels of serum TT (［16.01±5.41］ vs ［17.39±6.57］ nmol/L), SHBG (［58.91±36.89］ vs ［70.28±40.90］ nmol/L), and LH (［8.86±6.49］ vs ［10.85±11.73］ IU/L) (all P< 0.05) and a decreased level of FTI (0.33±0.15 vs 0.30±0.12, P< 0.05). There were no statistically significant differences between the nonvasectomy and vasectomy groups in cFT (［0.24±0.07］ vs ［0.23±0.09］ nmol/L) or TSI (［2.42±1.34］ vs ［2.46±1.51］ nmol/IU) (both P>0.05), nor after adjustment for relevant factors in TT (β: 1.015, 95% CI: －0.180－2.210), SHBG (β: 5.118, 95% CI: －2.069－12.305), cFT (β: 0.003, 95% CI: －0.011－0.018), FTI (β: －0.012, 95% CI: －0.035－0.011), TSI (β: 0.138, 95% CI: －0.131－0.407), and LH (β: 1.011, 95% CI: －0.811－2.834) (all P>0.05).

Conclusions: Vasectomy has no obvious longterm influence on the levels of serum androgens in aging males.

目的： 探讨输精管结扎术对男性中老年期血清雄激素水平的远期影响。 方法： 采用分层整群抽样的方法，抽取遵义地区40岁及以上成年男性437例(有输精管结扎史232例，无结扎史205例)进行问卷调查、体格检查，并检测其血清总睾酮(TT)、性激素结合球蛋白(SHBG)和黄体生成素(LH)，计算游离睾酮(cFT)、睾酮分泌指数(TSI)、游离睾酮指数(FTI)。结果： 结扎组TT(17.39±6.57) nmol/L、SHBG(70.28±40.90) nmol/L和LH(10.85±11.73) IU/L均显著高于非结扎组的(16.01±5.41) nmol/L、(58.91±36.89) nmol/L和(8.86±6.49) IU/L,P均< 0.05；结扎组FTI(0.30±0.12)显著低于非结扎组(0.33±0.15) ，P< 0.05；结扎组cFT(0.23±0.09) nmol/L、TSI(2.46±1.51) nmol/IU与非结扎组(0.24±0.07) nmol/L、(2.42±1.34) nmol/IU相比，差异无统计学意义（P均> 0.05）。校正相关因素后，结扎组与非结扎组相比，TT(β:1.015,95%CI:－0.180,2.210)、SHBG(β:5.118,95%CI:－2.069,12.305)、cFT(β:0.003,95%CI:－0.011,0.018)、FTI(β:－0.012,95%CI:－0.035，0.011)、TSI(β:0.138,95%CI:－0.131,0.407)、LH(β:1.011,95%CI:－0.811,2.834)差异均无统计学意义(P均>0.05)。结论： 输精管结扎术对男性中老年期血清雄激素水平未见明显的远期影响。.

Keywords: long term influence; aging male; androgen; vasectomy.

MeSH terms

  • Adult
  • Aged
  • Aging / blood*
  • Androgens / blood*
  • Humans
  • Luteinizing Hormone / blood
  • Male
  • Middle Aged
  • Physical Examination
  • Sex Hormone-Binding Globulin / analysis
  • Surveys and Questionnaires
  • Testosterone / blood
  • Time Factors
  • Vasectomy*

Substances

  • Androgens
  • Sex Hormone-Binding Globulin
  • Testosterone
  • Luteinizing Hormone