Current perspectives in Set7 mediated stem cell differentiation

Nazanin Karimnia; Haloom Rafehi; Natasha K Tuano; Mark Ziemann; Harikrishnan K N; Jun Okabe; Assam El-Osta

doi:10.3390/ncrna2040014

Current perspectives in Set7 mediated stem cell differentiation

Noncoding RNA. 2016 Dec 4;2(4):14. doi: 10.3390/ncrna2040014.

Authors

Nazanin Karimnia¹, Haloom Rafehi¹, Natasha K Tuano¹, Mark Ziemann¹, Harikrishnan K N^{1

2}, Jun Okabe^{1

3

4}, Assam El-Osta^{5

6

7

8

9}

Affiliations

¹ Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.
² Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia.
³ Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria 3004, Australia.
⁴ Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia.
⁵ Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia. assam.el-osta@bakeridi.edu.au.
⁶ Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia. assam.el-osta@bakeridi.edu.au.
⁷ Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria 3004, Australia. assam.el-osta@bakeridi.edu.au.
⁸ Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia. assam.el-osta@bakeridi.edu.au.
⁹ Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR. assam.el-osta@bakeridi.edu.au.

Abstract

Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity.

Keywords: Set7; histone; non-coding RNA; non-histone protein; stem cell differentiation.