Are We Eating Our Way to Prostate Cancer-A Hypothesis Based on the Evolution, Bioaccumulation, and Interspecific Transfer of miR-150

Venkatesh Vaidyanathan; Vetrivhel Krishnamoorthy; Nishi Karunasinghe; Anower Jabed; Radha Pallati; Chi Hsiu-Juei Kao; Alice Wang; Gareth Marlow; Lynnette R Ferguson

doi:10.3390/ncrna2020002

Are We Eating Our Way to Prostate Cancer-A Hypothesis Based on the Evolution, Bioaccumulation, and Interspecific Transfer of miR-150

Noncoding RNA. 2016 Apr 21;2(2):2. doi: 10.3390/ncrna2020002.

Authors

Venkatesh Vaidyanathan¹, Vetrivhel Krishnamoorthy², Nishi Karunasinghe³, Anower Jabed⁴, Radha Pallati⁵, Chi Hsiu-Juei Kao⁶, Alice Wang⁷, Gareth Marlow⁸, Lynnette R Ferguson^{9

10}

Affiliations

¹ Discipline of Nutrition and Dietetics, FM & HS, University of Auckland, Auckland 1023, New Zealand. v.vaidyanathan@auckland.ac.nz.
² Discipline of Nutrition and Dietetics, FM & HS, University of Auckland, Auckland 1023, New Zealand. vkri468@aucklanduni.ac.nz.
³ Auckland Cancer Society Research Centre, Auckland 1023, New Zealand. n.karunasinghe@auckland.ac.nz.
⁴ Department of Molecular Medicine and Pathology, FM & HS, University of Auckland, Auckland 1023, New Zealand. a.jabed@auckland.ac.nz.
⁵ Discipline of Nutrition and Dietetics, FM & HS, University of Auckland, Auckland 1023, New Zealand. rpal628@aucklanduni.ac.nz.
⁶ Discipline of Nutrition and Dietetics, FM & HS, University of Auckland, Auckland 1023, New Zealand. b.kao@auckland.ac.nz.
⁷ Discipline of Nutrition and Dietetics, FM & HS, University of Auckland, Auckland 1023, New Zealand. alice.wang@auckland.ac.nz.
⁸ Experimental Cancer Medicine Centre, Cardiff University, Cardiff, CF14 4XN, UK. MarlowG@cardiff.ac.uk.
⁹ Discipline of Nutrition and Dietetics, FM & HS, University of Auckland, Auckland 1023, New Zealand. l.ferguson@auckland.ac.nz.
¹⁰ Auckland Cancer Society Research Centre, Auckland 1023, New Zealand. l.ferguson@auckland.ac.nz.

Abstract

MicroRNAs (miRNAs) are well established epigenetic modifiers. There is a lot of work being done to identify the evolutionary transfer of miRNAs both at intra- and interspecific levels. In this hypothesis-driven review, we have suggested a possible reason as to why miR-150 can be a promising diagnostic biomarker for prostate cancer using theories of evolution, bio-accumulation, and interspecific transfer of miRNAs.

Keywords: bioaccumulation; evolution; miR-150; nutrigenomics; prostate cancer.