Free silanols and ionic liquids as their suppressors in liquid chromatography

Magdalena Buszewska-Forajta; Michał J Markuszewski; Roman Kaliszan

doi:10.1016/j.chroma.2018.04.002

Free silanols and ionic liquids as their suppressors in liquid chromatography

J Chromatogr A. 2018 Jul 20:1559:17-43. doi: 10.1016/j.chroma.2018.04.002. Epub 2018 Apr 7.

Authors

Magdalena Buszewska-Forajta¹, Michał J Markuszewski¹, Roman Kaliszan²

Affiliations

¹ Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Hallera 107, 30-216, Gdańsk, Poland.
² Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Hallera 107, 30-216, Gdańsk, Poland. Electronic address: roman.kaliszan@gumed.edu.pl.

PMID: 29655839
DOI: 10.1016/j.chroma.2018.04.002

Abstract

In this review, we will firstly discuss the types and the general properties of silica, focusing on the silica support used in chromatography and capillary electrophoresis. Additionally, the characterization of functional groups (silanols and siloxanes) will be considered in terms of activity of the stationary phases. We will then discuss physical chemistry of the stationary phases applied in liquid chromatography and capillary electrophoresis. The use of ionic liquids as a silanols' suppressors will be presented in the next parts of the study, along with the examples of specific applications. The review is completed with conclusions and an outlook for the future developments in the area of analytical applications of ionic liquids.

Keywords: CE; Free silanols; HPLC; Ionic liquids; Mobile phase additives.

Publication types

Review

MeSH terms

Chromatography, High Pressure Liquid
Chromatography, Liquid / methods*
Chromatography, Thin Layer / methods
Electrophoresis, Capillary / methods
Ionic Liquids / chemistry*
Silanes / chemistry*
Silicon Dioxide / chemistry
Surface Properties

Substances

Ionic Liquids
Silanes
silanol
Silicon Dioxide