Demonstration of the bactericidal effects of the boron neutron capture reaction

Appl Radiat Isot. 2018 Jul:137:190-193. doi: 10.1016/j.apradiso.2018.04.011. Epub 2018 Apr 5.

Abstract

This pilot study represents a paradigm shift, using BNCT for the treatment of bacterial overgrowth on surgically implanted medical devices. In this study, titanium diboride disks were inoculated with S. aureus and irradiated in a thermal neutron beam. After a delivery of 2.6 × 1012 n/cm2 the surviving fraction of S. aureus on an irradiated disk was 3.1 × 10-5 when compared with non-irradiated controls. This pilot study demonstrates proof of principle of boron neutron capture therapy for infection control (BNCIC).

Publication types

  • Evaluation Study

MeSH terms

  • Boron Compounds
  • Boron Neutron Capture Therapy / methods*
  • Computer Simulation
  • Humans
  • In Vitro Techniques
  • Infection Control / methods
  • Pilot Projects
  • Prosthesis-Related Infections / prevention & control
  • Prosthesis-Related Infections / radiotherapy*
  • Radiotherapy Dosage
  • Staphylococcal Infections / prevention & control
  • Staphylococcal Infections / radiotherapy*
  • Staphylococcus aureus / radiation effects*
  • Titanium

Substances

  • Boron Compounds
  • titanium boride
  • Titanium