Metabolic systems and the function of these systems are complex, involving biochemical pathways, endocrine, neuroendocrine systems, and physiological systems and interact with environmental conditions. Studies in animal models have been invaluable in gaining an understanding of the mechanisms involved in metabolic endocrine changes during normal aging and with conditions, such as diabetes and obesity. Together, these studies have revealed some conserved mechanisms and identified specific biomarkers of aging related to metabolic changes. Further, characterization of these mechanisms provides an opportunity to develop interventions and treatments for both humans and other vertebrates. This chapter will provide an overview of age-related changes in metabolism from studies in human populations and the perspective of information gained from comparative animal models. Detailed molecular mechanisms and endocrine pathways have already been discussed in other chapters of this volume. Finally, calorie restriction (CR) has shown consistent benefit to age-related disease incidence with effects that has been consistent across animal models These studies on the effects of CR enable further discernment of disease versus healthy aging processes.
Keywords: aging; calorie restriction; comparative models; metabolism.
Copyright © 2017. Published by Elsevier Inc.