RSRC1 and CPZ gene polymorphisms with neuroblastoma susceptibility in Chinese children

Gene. 2018 Jul 1:662:83-87. doi: 10.1016/j.gene.2018.04.015. Epub 2018 Apr 10.

Abstract

Two new neuroblastoma susceptibility loci at 3q25 (RSRC1 rs6441201 G > A) and 4p16 (CPZ rs3796725 T > C and rs3796727 A > G) were identified by a genome-wide association study (GWAS) involving Italians, African Americans and European Americans. In this case-control study with 393 neuroblastoma cases and 812 controls, we investigated the association between these three polymorphisms and neuroblastoma susceptibility in Chinese population. We found that participants harboring the RSRC1 rs6441201A allele were associated with an increased risk of neuroblastoma (AA vs. GG: adjusted OR = 1.55, 95% CI = 1.03-2.34, P = 0.036). No significant association between the CPZ polymorphisms (rs3796725 T > C and rs3796727A > G) and neuroblastoma susceptibility was observed. In conclusion, our results confirm that the RSRC1 rs6441201A allele is associated with neuroblastoma susceptibility in Chinese population.

Keywords: CPZ; Neuroblastoma; Polymorphism; RSRC1; Susceptibility.

MeSH terms

  • Alleles
  • Asian People / genetics
  • Carboxypeptidases / genetics*
  • Carboxypeptidases / metabolism
  • Case-Control Studies
  • Child
  • Child, Preschool
  • China
  • Female
  • Gene Frequency / genetics
  • Genetic Predisposition to Disease / genetics
  • Genome-Wide Association Study / methods
  • Genotype
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Neuroblastoma / genetics*
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • Odds Ratio
  • Polymorphism, Single Nucleotide / genetics
  • Risk Factors

Substances

  • Nuclear Proteins
  • RSRC1 protein, human
  • CPZ protein, human
  • Carboxypeptidases