Abstract
Covering: up to the end of 2017 The roles played by Rieske non-heme iron-dependent oxygenases in natural product biosynthesis are reviewed, with particular focus on experimentally characterised examples. Enzymes belonging to this class are known to catalyse a range of transformations, including oxidative carbocyclisation, N-oxygenation, C-hydroxylation and C-C desaturation. Examples of such enzymes that have yet to be experimentally investigated are also briefly described and their likely functions are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Biological Products / metabolism*
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Cyclization
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Electron Transport Complex III / chemistry*
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Electron Transport Complex III / metabolism
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Heme
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Heterocyclic Compounds, 3-Ring / chemistry
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Heterocyclic Compounds, 3-Ring / metabolism
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Hydroxylation
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Oxygenases / chemistry*
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Oxygenases / metabolism*
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Prodigiosin / analogs & derivatives
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Prodigiosin / biosynthesis
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Prodigiosin / chemistry
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Pyrroles / chemistry
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Pyrroles / metabolism
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Pyrrolnitrin / biosynthesis
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Spiro Compounds / metabolism
Substances
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Biological Products
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Heterocyclic Compounds, 3-Ring
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Pyrroles
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Rieske iron-sulfur protein
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Spiro Compounds
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marineosin A
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metacycloprodigiosin
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prodigiosin R1
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roseophilin
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streptorubin B
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prodiginine
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Heme
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Oxygenases
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Electron Transport Complex III
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Pyrrolnitrin
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Prodigiosin