Abstract
Bacteriophages sense alkaline cations in their immediate extracellular environment, which regulates virion-virion interactions. An ion-steerable aggregation-dispersion (A/D) phenomenon among virions is a recently discovered step in group behavior in the phage life cycle. When powered by the octanol-based water-immiscible lipopolysaccharide (LPS) trap (oWILT) purification approach, A/D promises breakthroughs for a plethora of biotechnological applications beyond phage therapy.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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1-Octanol / chemistry
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Animals
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Anti-Bacterial Agents / therapeutic use
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Bacteriophages / chemistry
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Bacteriophages / drug effects*
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Bacteriophages / physiology
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Cations, Monovalent
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Flocculation / drug effects
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Humans
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Lipopolysaccharides / chemistry
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Lysogeny / physiology
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Nanocapsules / chemistry
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Phage Therapy / methods*
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Potassium / chemistry
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Potassium / pharmacology*
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Precision Medicine / methods*
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Sodium / chemistry
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Sodium / pharmacology*
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Surface Properties
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Virion / chemistry
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Virion / drug effects*
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Virion / physiology
Substances
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Anti-Bacterial Agents
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Cations, Monovalent
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Lipopolysaccharides
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Nanocapsules
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Sodium
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1-Octanol
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Potassium