It Takes Two To Target: A Study in KRAS Dimerization

Biochemistry. 2018 Apr 24;57(16):2289-2290. doi: 10.1021/acs.biochem.8b00376. Epub 2018 Apr 12.

Authors

Behnam Nabet^{1

2}, Nathanael S Gray^{1

2}

Affiliations

¹ Department of Cancer Biology , Dana-Farber Cancer Institute , Boston , Massachusetts 02215 , United States.
² Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

PMID: 29648795
DOI: 10.1021/acs.biochem.8b00376

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylonitrile / adverse effects
Acrylonitrile / analogs & derivatives*
Acrylonitrile / therapeutic use
Adenocarcinoma / drug therapy*
Adenocarcinoma / genetics
Adenocarcinoma / pathology
Adenocarcinoma of Lung
Aniline Compounds / adverse effects
Aniline Compounds / therapeutic use*
Humans
Lung Neoplasms / drug therapy*
Lung Neoplasms / genetics
Lung Neoplasms / pathology
Mutation
Protein Multimerization / genetics
Proto-Oncogene Proteins p21(ras) / genetics*

Substances

Aniline Compounds
KRAS protein, human
MEK inhibitor I
Proto-Oncogene Proteins p21(ras)
Acrylonitrile