Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions

Louisa A Ho; Colin L Raston; Keith A Stubbs

doi:10.1002/chem.201801109

Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions

Chemistry. 2018 Jun 21;24(35):8869-8874. doi: 10.1002/chem.201801109. Epub 2018 Jun 1.

Authors

Louisa A Ho¹, Colin L Raston², Keith A Stubbs¹

Affiliations

¹ School of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
² Centre for Nanoscale Science and Technology, College of Science and Engineering, Flinders University, Sturt Road, Bedford Park, SA 5042, Australia.

PMID: 29645306
DOI: 10.1002/chem.201801109

Abstract

The dynamic thin film formed in an angled rapidly rotating tube in a vortex fluidic device (VFD) is effective in facilitating multicomponent reactions (MCRs) as photocatalytic or metal-mediated processes. Here, we demonstrate the utility of the VFD by using two known MCRs, an Ugi-type three component reaction and an A³ -coupling reaction. The Ugi-type reaction can be done in either confined or continuous-flow modes of operation of the microfluidic platform whereas the A³ -coupling reaction was optimized for the confined mode of operation. The examples tested gave excellent yields with short reaction times.

Keywords: A3 coupling; multicomponent reactions; photocatalysis; thin-film microfluidics; vortex fluidics.