Abstract
Chemical investigation of the marine sponge Dactylospongia elegans, collected from the South China Sea, afforded three new dimeric sesquiterpene quinones, popolohuanones G - I (1 - 3), together with two known analogs, popolohuanones B (4) and C (5). The new structures were determined by HR-ESI-MS and 1D- and 2D-NMR analyses. All the five compounds showed no cytotoxic activity against five human cancer cell lines, while popolohuanone H (2) showed potent inhibitory activity against IL-6, an inflammatory cytokine, at the concentration of 10 μm.
Keywords:
Dactylospongia elegans; anti-inflammatory activity; dimeric sesquiterpene quinones; marine sponge; popolohuanones G - I.
© 2018 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Interleukin-6 / antagonists & inhibitors*
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Interleukin-6 / biosynthesis
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology
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Molecular Conformation
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Porifera / chemistry*
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Quinones / chemistry
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Quinones / isolation & purification
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Quinones / pharmacology*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Interleukin-6
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Lipopolysaccharides
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Quinones
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Sesquiterpenes
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popolohuanone G
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popolohuanone H
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popolohuanone I