Immune regulation of the unfolded protein response at the mucosal barrier in viral infection

Ran Wang; Md Moniruzzaman; Eric Shuffle; Rohan Lourie; Sumaira Z Hasnain

doi:10.1002/cti2.1014

Immune regulation of the unfolded protein response at the mucosal barrier in viral infection

Clin Transl Immunology. 2018 Apr 3;7(4):e1014. doi: 10.1002/cti2.1014. eCollection 2018.

Authors

Ran Wang^{1

2}, Md Moniruzzaman^{1

2}, Eric Shuffle¹, Rohan Lourie^{1

3}, Sumaira Z Hasnain^{1

2}

Affiliations

¹ Translational Research Institute Immunopathology Group at Mater Research Institute - The University of Queensland Brisbane QLD Australia.
² Faculty of Medicine The University of Queensland Brisbane QLD Australia.
³ Translational Research Institute Inflammatory Bowel Disease Group at Mater Research Institute - The University of Queensland Brisbane QLD Australia.

Abstract

Protein folding in the endoplasmic reticulum (ER) is subject to stringent quality control. When protein secretion demand exceeds the protein folding capacity of the ER, the unfolded protein response (UPR) is triggered as a consequence of ER stress. Due to the secretory function of epithelial cells, UPR plays an important role in maintaining epithelial barrier function at mucosal sites. ER stress and activation of the UPR are natural mechanisms by which mucosal epithelial cells combat viral infections. In this review, we discuss the important role of UPR in regulating mucosal epithelium homeostasis. In addition, we review current insights into how the UPR is involved in viral infection at mucosal barriers and potential therapeutic strategies that restore epithelial cell integrity following acute viral infections via cytokine and cellular stress manipulation.

Keywords: endoplasmic reticulum stress; epithelial cells; mucosal barrier; unfolded protein response; viral infection.

Publication types

Review