WITHDRAWN: Very low density lipoprotein receptor deficiency prevents obesity-induced cardiac lipotoxicity

J Biol Chem. 2018 Apr 9:jbc.M117.813303. doi: 10.1074/jbc.M117.813303. Online ahead of print.

Abstract

This article has been withdrawn by the authors. We have become aware of errors in the construction of Figs 1 and 2. In Fig 1D, the tIRS1 immunoblot from untreated cardiomyocytes was inadvertently reused from Fig 2A of PLOS One 2016 May 19;11(5):e0155611. Also in Fig 1D, there were undeclared gel splices with no line indicating the assemblage of two parts in the pIRS1 immunoblot from insulin-stimulated cardiomyocytes. In Fig 2B, lanes 1-3 and lanes 5-7 of the actin immunoblot were mistakenly duplicated. Because some of the original data are no longer available, the authors wish to withdraw this article. However, the authors have full confidence in the findings and conclusions of this paper, and will repeat the missing immunoblots to complete the paper.

Keywords: insulin resistance; lipid; lipotoxicity; obesity; oxidative stress.