Anticomplement compounds from Polygonum chinense

Bioorg Med Chem Lett. 2018 May 15;28(9):1495-1500. doi: 10.1016/j.bmcl.2018.03.079. Epub 2018 Mar 29.

Abstract

Five new compounds including two phenyldilactones (1, 2), two coumarins (3, 4) and a dimer of N-E-feruloyl tyramine (5) together with twenty-three known compounds (6-28) were isolated from a medicinal plant Polygonum chinense. The structures of the new compounds were established by detailed spectral analysis. The absolute configurations of 1 and 5 were elucidated by Mosher's method, Mo2(OAc)4-induced electronic circular dichroism (ECD) data, and ECD calculation. All the compounds were found to show potent anticomplement activity with CH50 and AP50 values ranging from 0.18 to 1.45 mM, and 0.26 to 2.80 mM, respectively. Phenyldilactones and phenylpropionic tyramines were firstly reported as anticomplement agents. The targets of compounds 1, 3, 5 and 10 in complement activation cascade were identified as well.

Keywords: Anticomplement; Phenyldilactones; Phenylpropionic tyramines; Polygonum chinense; Traditional Chinese medicines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Complement Inactivator Proteins / chemistry
  • Complement Inactivator Proteins / isolation & purification
  • Complement Inactivator Proteins / pharmacology*
  • Coumarins / chemistry
  • Coumarins / isolation & purification
  • Coumarins / pharmacology*
  • Dose-Response Relationship, Drug
  • Hemolysis / drug effects*
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Lactones / pharmacology*
  • Molecular Structure
  • Plants, Medicinal
  • Polygonum / chemistry*
  • Structure-Activity Relationship
  • Tyramine / analogs & derivatives
  • Tyramine / chemistry
  • Tyramine / pharmacology*

Substances

  • Complement Inactivator Proteins
  • Coumarins
  • Lactones
  • anticomplement
  • Tyramine