Pemphigoid gestationis successfully treated with intravenous immunoglobulin

BMJ Case Rep. 2018 Apr 7:2018:bcr2018224346. doi: 10.1136/bcr-2018-224346.

Abstract

Pemphigoid gestationis (PG), also known as herpes gestationis, is a rare autoimmune blistering disease specific to pregnancy, which usually presents in the second or third trimesters and, in 15%-25% of cases, during the immediate postpartum period.1Although the ethiopathogeny of PG is not fully clarified, most patients develop antibodies against a 180 kDa transmembrane hemidesmosomal protein (BP180; BPAG2; collagen XVII).2 PG has a strong association with human leucocyte antigens DR3 and DR4.3We report a case of a 29-year-old female patient with PG successfully treated with intravenous immunoglobulin.

Keywords: dermatology; obstetrics and gynaecology; obstetrics, gynaecology and fertility.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage*
  • Immunoglobulins, Intravenous / therapeutic use*
  • Pemphigoid Gestationis / diagnosis*
  • Pemphigoid Gestationis / drug therapy*
  • Pemphigoid Gestationis / immunology
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Trimester, Third
  • Treatment Outcome

Substances

  • Immunoglobulins, Intravenous