Evaluation of the intracellular activity of drugs against Mycobacterium abscessus using a THP-1 macrophage model

J Microbiol Methods. 2018 May:148:29-32. doi: 10.1016/j.mimet.2018.03.020. Epub 2018 Apr 4.

Abstract

We evaluated the antimicrobial effectiveness against M. abscessus in a THP-1 cell line model. No intracellular activity was observed when using amikacin or imipenem. A bacteriostatic effect was observed for cefoxitin, clarithromycin and azithromycin. Tigecycline showed the best antibacterial effect by decreasing the intracellular growth up to bactericidal level.

Keywords: Intracellular activity; Mycobacterium abscessus; THP-1 macrophages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / pharmacology*
  • Humans
  • Macrophages / metabolism*
  • Macrophages / microbiology*
  • Microbial Viability / drug effects
  • Models, Biological
  • Mycobacterium Infections, Nontuberculous / drug therapy
  • Mycobacterium abscessus / drug effects*
  • Mycobacterium abscessus / growth & development
  • THP-1 Cells

Substances

  • Anti-Bacterial Agents