Drug delivery systems and materials for wound healing applications

Saghi Saghazadeh; Chiara Rinoldi; Maik Schot; Sara Saheb Kashaf; Fatemeh Sharifi; Elmira Jalilian; Kristo Nuutila; Giorgio Giatsidis; Pooria Mostafalu; Hossein Derakhshandeh; Kan Yue; Wojciech Swieszkowski; Adnan Memic; Ali Tamayol; Ali Khademhosseini

doi:10.1016/j.addr.2018.04.008

Drug delivery systems and materials for wound healing applications

Adv Drug Deliv Rev. 2018 Mar 1:127:138-166. doi: 10.1016/j.addr.2018.04.008. Epub 2018 Apr 5.

Authors

Affiliations

¹ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
² Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw 02-507, Poland.
³ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; MIRA Institute of Biomedical Technology and Technical Medicine, Department of Developmental BioEngineering, University of Twente, Enschede, The Netherlands.
⁴ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The University of Chicago Medical Scientist Training Program, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
⁵ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
⁶ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; UCL Institute of Ophthalmology, University College London, London, EC1V 9EL, United Kingdom.
⁷ Division of Plastic Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.
⁸ Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68508, USA.
⁹ Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw 02-507, Poland.
¹⁰ Center of Nanotechnology, King Abdulaziz University, Jeddah 21569, Saudi Arabia.
¹¹ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68508, USA. Electronic address: atamayol@unl.edu.
¹² Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center of Nanotechnology, King Abdulaziz University, Jeddah 21569, Saudi Arabia; Department of Chemical and Biomolecular Engineering, California NanoSystems Institute (CNSI), University of California, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, CA 90095, USA; Department of Radiology, University of California, Los Angeles, CA 90095, USA; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia. Electronic address: khademh@ucla.edu.

Abstract

Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted.

Keywords: Drug delivery; Microtechnologies; Nanotechnologies; Transdermal delivery; Wound healing.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Biocompatible Materials / administration & dosage*
Biocompatible Materials / metabolism
Biocompatible Materials / pharmacokinetics
Biocompatible Materials / pharmacology*
Drug Delivery Systems*
Humans
Skin / drug effects
Skin / metabolism
Wound Healing / drug effects*

Substances

Biocompatible Materials

Abstract

Publication types

MeSH terms

Substances

Grants and funding