Comparison of five cell-free DNA isolation methods to detect the EGFR T790M mutation in plasma samples of patients with lung cancer

Clin Chem Lab Med. 2018 Aug 28;56(9):e243-e246. doi: 10.1515/cclm-2017-0967.

Jérôme Solassol^{1

2

3}, Xavier Quantin⁴, Marion Larrieux¹, Romain Senal², Patricia Audran², David Grand⁵, Alain Mangé³, Eleftherios P Diamandis^{6

7

8}, Julie A Vendrell¹

¹ Department of Pathology, CHU Montpellier, University of Montpellier, Montpellier, France.
² Department of Biopathology, Institut du Cancer de Montpellier (ICM), University of Montpellier, Montpellier, France.
³ Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, University of Montpellier, Montpellier, France.
⁴ Department of Thoracic Oncology, CHU Montpellier, University of Montpellier, Montpellier, France.
⁵ Department of Pathology, Institut Universitaire du Cancer Toulouse Oncopole, CHU de Toulouse, Toulouse, France.
⁶ Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada.
⁷ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
⁸ Department of Clinical Biochemistry, University Health Network, Toronto, Canada.

No abstract available

Keywords: EGFR mutation; circulating tumor DNA; droplet digital PCR; lung cancer; targeted therapy.

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