Agerarin inhibits α-MSH-induced TYR gene transcription via STAT3 suppression independent of CREB-MITF pathway

J Dermatol Sci. 2018 Jul;91(1):107-110. doi: 10.1016/j.jdermsci.2018.03.014. Epub 2018 Mar 30.

Authors

Soon Young Shin¹, Ha-Na Gil², Ji Hye Choi², Yoongho Lim³, Young Han Lee⁴

Affiliations

¹ Department of Biological Sciences, Sanghuh College of Life Sciences, Konkuk University, Seoul, Republic of Korea; Cancer and Metabolism Institute, Konkuk University, Seoul, Republic of Korea.
² Department of Biological Sciences, Sanghuh College of Life Sciences, Konkuk University, Seoul, Republic of Korea.
³ Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul, Republic of Korea.
⁴ Department of Biological Sciences, Sanghuh College of Life Sciences, Konkuk University, Seoul, Republic of Korea; Cancer and Metabolism Institute, Konkuk University, Seoul, Republic of Korea. Electronic address: yhlee58@konkuk.ac.kr.

PMID: 29625721
DOI: 10.1016/j.jdermsci.2018.03.014

No abstract available

Publication types

Letter

MeSH terms

Animals
Benzopyrans / pharmacology*
Cell Line, Tumor
Cyclic AMP Response Element-Binding Protein / metabolism*
Melanins / biosynthesis*
Melanocytes / drug effects*
Melanocytes / enzymology
Melanocytes / pathology
Melanoma, Experimental / enzymology
Melanoma, Experimental / genetics
Melanoma, Experimental / pathology
Mice
Microphthalmia-Associated Transcription Factor / genetics
Microphthalmia-Associated Transcription Factor / metabolism*
Monophenol Monooxygenase / genetics
Monophenol Monooxygenase / metabolism*
Phosphorylation
STAT3 Transcription Factor / metabolism*
Signal Transduction / drug effects
Skin Pigmentation / drug effects*
Transcription, Genetic / drug effects*
alpha-MSH / pharmacology*

Substances

Benzopyrans
Creb1 protein, mouse
Cyclic AMP Response Element-Binding Protein
Melanins
Microphthalmia-Associated Transcription Factor
Mitf protein, mouse
STAT3 Transcription Factor
Stat3 protein, mouse
agerarin
alpha-MSH
Monophenol Monooxygenase