Building Bonds: Cancer Stem Cells Depend on Their Progeny to Drive Tumor Progression

Sree Deepthi Muthukrishnan; Alvaro G Alvarado; Harley I Kornblum

doi:10.1016/j.stem.2018.03.008

Building Bonds: Cancer Stem Cells Depend on Their Progeny to Drive Tumor Progression

Cell Stem Cell. 2018 Apr 5;22(4):473-474. doi: 10.1016/j.stem.2018.03.008.

Authors

Sree Deepthi Muthukrishnan¹, Alvaro G Alvarado¹, Harley I Kornblum²

Affiliations

¹ The Intellectual and Developmental Disabilities Research Center, The Semel Institute for Neuroscience and Human Behavior, and The Broad Stem Cell Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
² The Intellectual and Developmental Disabilities Research Center, The Semel Institute for Neuroscience and Human Behavior, and The Broad Stem Cell Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; The Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: hkornblum@mednet.ucla.edu.

Abstract

Little is currently known about how cancer stem-like cells (CSCs) interact with their more restricted progeny. In this issue of Cell Stem Cell, Wang et al. (2018) demonstrate a novel bidirectional signaling axis between CSCs and their progeny that is mediated by brain-derived neurotrophic factor and VGF accelerating glioma progression.

Publication types

Comment

MeSH terms

Adult
Cell Differentiation
Glioblastoma*
Glioma*
Humans
Neoplastic Stem Cells
Signal Transduction

Grants and funding

U54 HD087101/HD/NICHD NIH HHS/United States