Abstract
Seven new acetophenone derivatives (acroliones A - G, 1 - 7) and three known ones (8 - 10) were isolated from the leaves of Acronychia oligophlebia. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, HR-ESI-MS, 1D- and 2D-NMR), X-ray diffraction and comparison with literature data. The anti-inflammatory and antioxidant activities of all isolates were evaluated.
Keywords:
Acronychia oligophlebia; acetophenone derivatives; anti-inflammatory activity; antioxidant activity; structural elucidation.
© 2018 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Acetophenones / chemistry
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Acetophenones / isolation & purification
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Acetophenones / pharmacology*
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Biphenyl Compounds / antagonists & inhibitors*
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Crystallography, X-Ray
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Mice
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Models, Molecular
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide / biosynthesis
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Picrates / antagonists & inhibitors*
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Plant Leaves / chemistry
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RAW 264.7 Cells
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Rutaceae / chemistry*
Substances
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Acetophenones
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Anti-Inflammatory Agents, Non-Steroidal
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Antioxidants
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Biphenyl Compounds
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Picrates
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Nitric Oxide
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1,1-diphenyl-2-picrylhydrazyl
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acetophenone