New Acetophenone Derivatives from Acronychia oligophlebia and Their Anti-inflammatory and Antioxidant Activities

Chem Biodivers. 2018 May;15(5):e18000080. doi: 10.1002/cbdv.201800080. Epub 2018 May 3.

Abstract

Seven new acetophenone derivatives (acroliones A - G, 1 - 7) and three known ones (8 - 10) were isolated from the leaves of Acronychia oligophlebia. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, HR-ESI-MS, 1D- and 2D-NMR), X-ray diffraction and comparison with literature data. The anti-inflammatory and antioxidant activities of all isolates were evaluated.

Keywords: Acronychia oligophlebia; acetophenone derivatives; anti-inflammatory activity; antioxidant activity; structural elucidation.

MeSH terms

  • Acetophenones / chemistry
  • Acetophenones / isolation & purification
  • Acetophenones / pharmacology*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Biphenyl Compounds / antagonists & inhibitors*
  • Crystallography, X-Ray
  • Mice
  • Models, Molecular
  • Molecular Structure
  • Nitric Oxide / antagonists & inhibitors*
  • Nitric Oxide / biosynthesis
  • Picrates / antagonists & inhibitors*
  • Plant Leaves / chemistry
  • RAW 264.7 Cells
  • Rutaceae / chemistry*

Substances

  • Acetophenones
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Biphenyl Compounds
  • Picrates
  • Nitric Oxide
  • 1,1-diphenyl-2-picrylhydrazyl
  • acetophenone