RNA capping by mitochondrial and multi-subunit RNA polymerases

Transcription. 2018;9(5):292-297. doi: 10.1080/21541264.2018.1456258. Epub 2018 Apr 25.

Abstract

Recently, it was found that bacterial and eukaryotic transcripts are capped with cellular cofactors installed by their respective RNA polymerases (RNAPs) during transcription initiation. We now show that mitochondrial RNAP efficiently caps transcripts with ADP - containing cofactors. However, a functional role of universal RNAP - catalysed capping is not yet clear.

Keywords: FAD; NAD+; RNA capping; RNA polymerase; UDP-GlcNAc; dephospho coenzymeA; mitochondrial RNA polymerase; non-canonical capping; transcription.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Diphosphate / genetics
  • Adenosine Diphosphate / metabolism
  • Bacteria / enzymology
  • Coenzyme A / genetics
  • Coenzyme A / metabolism
  • DNA-Directed RNA Polymerases / genetics
  • DNA-Directed RNA Polymerases / metabolism*
  • Eukaryota / enzymology
  • Flavin-Adenine Dinucleotide / metabolism
  • Humans
  • Mitochondria / enzymology*
  • Molecular Conformation
  • NAD / genetics
  • NAD / metabolism
  • Promoter Regions, Genetic
  • RNA / genetics
  • RNA / metabolism*
  • RNA Caps / chemistry*
  • Transcription, Genetic*

Substances

  • RNA Caps
  • NAD
  • Flavin-Adenine Dinucleotide
  • dephosphocoenzyme A
  • Adenosine Diphosphate
  • RNA
  • DNA-Directed RNA Polymerases
  • Coenzyme A