Bioactive Oleic Derivatives of Dopamine: A Review of the Therapeutic Potential

Adv Exp Med Biol. 2018:1096:73-82. doi: 10.1007/5584_2018_197.

Abstract

Lipid derivatives of dopamine are a novel class of compounds raising a research interest due to the potential of their being a vehicle for dopamine delivery to the brain. The aim of the present paper is to review the main features of the two most prominent bioactive members of this family, namely, N-oleoyl-dopamine (OLDA) and 3'-O-methyl-N-oleoyl-dopamine (OMe-OLDA), with emphasis on the possible therapeutic properties.

Keywords: Brain; Dopamine receptor; Lipid derivatives of dopamine; TRPV1 receptors; Therapeutic potential.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / metabolism*
  • Dopamine / analogs & derivatives*
  • Dopamine / chemistry
  • Dopamine / metabolism*
  • Dopamine / pharmacology
  • Molecular Structure
  • Motor Activity / drug effects
  • Oxygen Consumption / drug effects
  • Protein Binding
  • TRPV Cation Channels / metabolism*

Substances

  • TRPV Cation Channels
  • TRPV1 receptor
  • N-oleoyldopamine
  • Dopamine