Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2(1 H)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds.
Keywords: 6-methylpyrazin-2(1H)-one; Ugi reaction; allene; multicomponent reaction (MCR); substituted furans.