Clinical pharmacogenetics: how do we ensure a favorable future for patients?

Tim Wiltshire; Olivia M Dong

doi:10.2217/pgs-2017-0192

Clinical pharmacogenetics: how do we ensure a favorable future for patients?

Pharmacogenomics. 2018 Apr;19(6):553-562. doi: 10.2217/pgs-2017-0192. Epub 2018 Apr 5.

Authors

Tim Wiltshire^{1

2

3}, Olivia M Dong^{1

2}

Affiliations

¹ Division of Pharmacotherapy & Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
² Center for Pharmacogenomics & Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
³ Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

PMID: 29620450
DOI: 10.2217/pgs-2017-0192

Abstract

Currently, there is sufficient evidence for the use of pharmacogenetic information to optimize medication prescribing, but why has this information not been integrated into the drug prescribing process to improve patient care? A discussion about the major contributing factors that have limited the use of pharmacogenetic information in the drug prescribing process, the solutions to ensure widespread uptake, and a vision for the future of the pharmacogenetic field will be explored.

Keywords: pharmacogenetics; pharmacogenomics; precision medicine; preemptive genotyping.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Delivery of Health Care
Drug Prescriptions*
Genomics / trends*
Genotype
Humans
Pharmacogenetics / trends*
Pharmacogenomic Testing
Precision Medicine*