Emerging Strategies on Adjuvant Therapies for Nerve Recovery

J Hand Surg Am. 2018 Apr;43(4):368-373. doi: 10.1016/j.jhsa.2018.01.023.

Abstract

Current strategies for promoting faster and more effective peripheral nerve healing have utilized a wide variety of techniques and approaches. Nerve grafts, conduits, and stem cell therapy all have their respective advantages. However, there are still some difficulties in attaining complete functional recovery with a single treatment modality. The utilization of adjuvant treatments, in combination with current standard-of-care methods, offers the potential to improve patient outcomes. This paper highlights the current landscape of adjuvant treatments for enhancing peripheral nerve repair and regeneration.

Keywords: Peripheral nerve; adjuvant; drug; injury.

Publication types

  • Review

MeSH terms

  • Absorbable Implants
  • Allografts
  • Autografts
  • Calcium Channel Blockers / pharmacology
  • Erythropoietin / pharmacology
  • Gabapentin / pharmacology
  • Humans
  • Immunosuppressive Agents / pharmacology
  • Lithium Compounds / pharmacology
  • Nerve Regeneration*
  • Neuroprotective Agents / pharmacology
  • Neurosurgical Procedures / instrumentation
  • Peripheral Nerve Injuries / therapy*
  • Peripheral Nerves / transplantation
  • Recovery of Function
  • Riluzole / pharmacology
  • Stem Cell Transplantation
  • Valproic Acid / pharmacology
  • Veins / transplantation
  • Wallerian Degeneration / therapy

Substances

  • Calcium Channel Blockers
  • Immunosuppressive Agents
  • Lithium Compounds
  • Neuroprotective Agents
  • Erythropoietin
  • Valproic Acid
  • Gabapentin
  • Riluzole