Without Adaptive Immunity, There's a Cost to Responding STAT

Eric M Brown; Ramnik J Xavier

doi:10.1016/j.cmet.2018.03.011

Without Adaptive Immunity, There's a Cost to Responding STAT

Cell Metab. 2018 Apr 3;27(4):705-707. doi: 10.1016/j.cmet.2018.03.011.

Authors

Eric M Brown¹, Ramnik J Xavier²

Affiliations

¹ Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
² Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: xavier@molbio.mgh.harvard.edu.

PMID: 29617636
DOI: 10.1016/j.cmet.2018.03.011

Abstract

The relative contributions of innate and adaptive immune mechanisms in responding to the intestinal microbiota during ontogeny are largely unknown. A recent study in Nature by Mao et al. (2018) elegantly dissects the role of each cell type in the intestine and further describes the metabolic cost to innate immunity.

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MeSH terms

Adaptive Immunity
Gastrointestinal Microbiome*
Immunity, Innate
Lipid Metabolism
Lymphocytes