Early TCR Signaling Sweetens Effector Function through PDHK1

Nina Weisshaar; Alaa Madi; Guoliang Cui

doi:10.1016/j.tem.2018.03.016

Early TCR Signaling Sweetens Effector Function through PDHK1

Trends Endocrinol Metab. 2018 Sep;29(9):595-597. doi: 10.1016/j.tem.2018.03.016. Epub 2018 Mar 31.

Authors

Nina Weisshaar¹, Alaa Madi¹, Guoliang Cui²

Affiliations

¹ T Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany; These authors contributed equally.
² T Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany. Electronic address: g.cui@dkfz.de.

PMID: 29615303
DOI: 10.1016/j.tem.2018.03.016

Abstract

T cells rapidly engage glycolysis upon activation. The signaling pathways through which T cell receptor (TCR) activation initiates glycolysis have been a mystery. A long-awaited answer has been provided by Menk et al., who show that pyruvate dehydrogenase kinase 1 (PDHK1) is in the center of signaling events linking TCR activation to glycolysis.

Keywords: PDHK1; T cell activation; TCR signaling; glycolysis.

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MeSH terms

Citric Acid Cycle
Glycolysis*
Signal Transduction
T-Lymphocytes*