Inhibitors of Selected Bacterial Metalloenzymes

Curr Med Chem. 2019;26(15):2690-2714. doi: 10.2174/0929867325666180403154018.

Abstract

The utilization of bacterial metalloenzymes, especially ones not having mammalian (human) counterparts, has drawn attention to develop novel antibacterial agents to overcome drug resistance and especially multidrug resistance. In this review, we focus on the recent achievements on the development of inhibitors of bacterial enzymes peptide deformylase (PDF), metallo-β-lactamase (MBL), methionine aminopeptidase (MetAP) and UDP-3-O-acyl- N-acetylglucosamine deacetylase (LpxC). The state of the art of the design and investigation of inhibitors of bacterial metalloenzymes is presented, and challenges are outlined and discussed.

Keywords: Metalloenzymes; UDP-3-O-acylglucosamine deacetylase; bacteria; inhibitors; metallo-β- lactamase; methionine aminopeptidase; peptide deformylase..

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / enzymology*
  • Bacterial Proteins / antagonists & inhibitors*
  • Bacterial Proteins / chemistry
  • Catalytic Domain
  • Cell Line, Tumor
  • Drug Design
  • Humans
  • Metalloproteins / antagonists & inhibitors*
  • Metalloproteins / chemistry
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology
  • beta-Lactamase Inhibitors / chemistry
  • beta-Lactamase Inhibitors / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Metalloproteins
  • Protease Inhibitors
  • beta-Lactamase Inhibitors