Pharmacokinetics of Daptomycin in Critically Ill Pediatric Patients

Antimicrob Agents Chemother. 2018 May 25;62(6):e02462-17. doi: 10.1128/AAC.02462-17. Print 2018 Jun.

Abstract

The pharmacokinetics of daptomycin (10 mg/kg once daily) was studied in 4 critically ill pediatric patients aged 8 to 14 yrs. The area under the concentration-time curve from time zero to infinity (AUC0-∞) of plasma concentrations on day 1 ranged between 123.8 to 663.9 μg · h/ml, with lower values observed in septic and burn patients; clearance ranged from 15.1 to 80.7 ml/h/kg. Higher-than-recommended doses of daptomycin may be needed in septic children to ensure optimal drug exposure. Interpatient variability may suggest a role for therapeutic drug monitoring.

Keywords: burn; children; critically ill; daptomycin; pharmacokinetics; sepsis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / pharmacokinetics*
  • Burns / metabolism
  • Child
  • Critical Illness
  • Daptomycin / pharmacokinetics*
  • Female
  • Humans
  • Male
  • Sepsis / metabolism

Substances

  • Anti-Bacterial Agents
  • Daptomycin