Malignant Pleural Mesothelioma with Bone Marrow Metastases

Intern Med. 2018 Sep 1;57(17):2541-2545. doi: 10.2169/internalmedicine.9246-17. Epub 2018 Mar 30.

Abstract

A 64-year-old man with the bone marrow metastasis due to malignant pleural mesothelioma (MPM) was diagnosed with anemia, leukoerythroblastosis, thrombocytopenia, and lower back pain. A bone marrow biopsy demonstrated infiltrative malignant mesothelioma lesions in the bone marrow. The patient died within 15 days of the detection of the bone marrow involvement. Physicians should consider performing a bone marrow biopsy to diagnose bone marrow metastasis and treat patients with palliative chemotherapy at an earlier phase of the disease. To our knowledge, this is the first report of an MPM patient having bone marrow metastasis with anemia, leukoerythroblastosis, and thrombocytopenia.

Keywords: anemia; bone marrow metastasis; leukoerythroblastosis; malignant pleural mesothelioma; thrombocytopenia.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Bone Neoplasms / secondary*
  • Humans
  • Low Back Pain / etiology
  • Male
  • Mesothelioma / complications
  • Mesothelioma / diagnosis
  • Mesothelioma / pathology*
  • Middle Aged
  • Pleural Neoplasms / complications
  • Pleural Neoplasms / diagnosis
  • Pleural Neoplasms / pathology*