Inverted U-shaped curve relationship between red blood cell distribution width and hypertension in a large health checkup population in China

Mingfei Jiang; Xiaojuan Zha; Zewei Wu; Xinying Zhu; Wenbo Li; Huan Wu; Jun Ma; Shuyi Wang; Yufeng Wen

doi:10.1016/j.jash.2018.03.003

Inverted U-shaped curve relationship between red blood cell distribution width and hypertension in a large health checkup population in China

J Am Soc Hypertens. 2018 May;12(5):327-334. doi: 10.1016/j.jash.2018.03.003. Epub 2018 Mar 10.

Authors

Mingfei Jiang¹, Xiaojuan Zha², Zewei Wu¹, Xinying Zhu¹, Wenbo Li³, Huan Wu¹, Jun Ma¹, Shuyi Wang¹, Yufeng Wen⁴

Affiliations

¹ School of Laboratory Medicine, Wannan Medical College, Wuhu City, Anhui Province, China.
² First Affiliated Hospital, Wannan Medical College, Wuhu City, Anhui Province, China.
³ School of Clinical Medicine, Wannan Medical College, Wuhu City, Anhui Province, China.
⁴ School of Laboratory Medicine, Wannan Medical College, Wuhu City, Anhui Province, China. Electronic address: wyf@wnmc.edu.cn.

PMID: 29606529
DOI: 10.1016/j.jash.2018.03.003

Abstract

This study was aimed at investigating the relationship between red blood cell distribution width (RDW) and hypertension in a large health check up population in China. A population of 302,527 subjects from Wuhu was enrolled in this cross-sectional health check up study between 2011 and 2016. They consisted of 126,369 women (41.78%) and 176,158 men (58.23%) with mean age of 46.9 ± 13.4 and 48.1 ± 13.7 years, respectively. The investigations included information on demographic characteristics, physical examination, and laboratory testing. Inverted U-shape relationships were observed between RDW and hypertension with peak RDW values of 14.2 (women) and 15.2 (men). After stratification by sex and adjusted with body mass index, age, white blood cells, and high-density lipoprotein cholesterol, inverted U-shape relationships were also established between RDW and hypertension, systolic blood pressure, and diastolic blood pressure, with peak RDW of 14.2, 14.5, 14.5 in women and 14.2, 16.0, 14.5 in men. Inverted U-shape relationship exists between RDW and hypertension, systolic blood pressure, and diastolic blood pressure among the Chinese health check up population studied.

Keywords: Blood pressure; hypertension; red blood cell distribution width; risk factor.