Microwave-assisted green synthesis of 4,5-dihydro-1H-pyrazole-1-carbothioamides in water

Hamid Reza Farmani; Mohammad Hossein Mosslemin; Bahareh Sadeghi

doi:10.1007/s11030-018-9814-7

Microwave-assisted green synthesis of 4,5-dihydro-1H-pyrazole-1-carbothioamides in water

Mol Divers. 2018 Aug;22(3):743-749. doi: 10.1007/s11030-018-9814-7. Epub 2018 Mar 31.

Authors

Hamid Reza Farmani¹, Mohammad Hossein Mosslemin², Bahareh Sadeghi²

Affiliations

¹ Department of Chemistry, Yazd Branch, Islamic Azad University, P.O. Box 89195-155, Yazd, Iran. Hrfarmani@iauyazd.ac.ir.
² Department of Chemistry, Yazd Branch, Islamic Azad University, P.O. Box 89195-155, Yazd, Iran.

PMID: 29605835
DOI: 10.1007/s11030-018-9814-7

Abstract

Rapid, efficient, simple and green procedure for the synthesis of 4,5-dihydro-1H-pyrazole-1-carbothioamides via the multicomponent reaction of aryl aldehydes, acetophenones and thiosemicarbazide in water in the presence of tetrabutylammonium hydroxide under microwave irradiation is reported.

Keywords: 4,5-Dihydro-1H-pyrazole-1-carbothioamides; Green chemistry; MCRs; Microwave irradiation; Multicomponent reaction; TBAOH; Water.

MeSH terms

Acetophenones / chemistry
Aldehydes / chemistry
Green Chemistry Technology
Microwaves
Quaternary Ammonium Compounds / chemistry
Semicarbazides / chemistry
Thioamides / chemical synthesis*
Water / chemistry

Substances

Acetophenones
Aldehydes
Quaternary Ammonium Compounds
Semicarbazides
Thioamides
Water
thiosemicarbazide
tetrabutylammonium
acetophenone