CYP-Mediated Drug-Drug Interaction Is Not a Major Determinant of Attenuation of Antiplatelet Function of Clopidogrel by Vonoprazan

Clin Pharmacol Ther. 2018 Jul;104(1):31-32. doi: 10.1002/cpt.1060. Epub 2018 Mar 30.

Authors

Mitsuhiro Nishihara¹, Richard Czerniak²

Affiliations

¹ Global Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA.
² Quantitative Clinical Pharmacology, Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA.

PMID: 29603200
DOI: 10.1002/cpt.1060

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Clopidogrel*
Cytochrome P-450 CYP2C19
Drug Interactions
Esomeprazole*
Genotype
Prasugrel Hydrochloride
Pyrroles
Sulfonamides

Substances

1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine
Pyrroles
Sulfonamides
Clopidogrel
Cytochrome P-450 CYP2C19
Prasugrel Hydrochloride
Esomeprazole