Steroidal Constituents from Roots and Rhizomes of Smilacina japonica

Molecules. 2018 Mar 30;23(4):798. doi: 10.3390/molecules23040798.

Abstract

Four new steroidal constituents (1-4) along with two known steroidal glycosides (5 and 6) were isolated from the roots and rhizomes of Smilacina japonica. Analysis of their physicochemical properties and spectroscopic profiles identified the compounds as (25S)-5α-spirostan-9(11)-en-3β, 17α-diol (1); (25S)-5α-spirostan-9(11)-en-3β, 12β-diol (2); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranoside (3); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-galactopyranoside (4); japonicoside B (5); and japonicoside C (6). All six compounds showed cytotoxic activity against SMMC-7712, Bel-7402, A549, H460, and K562 human cancer cells.

Keywords: Smilacina japonica; cytotoxicity; steroidal constituents; structure identification.

MeSH terms

  • A549 Cells
  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / isolation & purification
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Humans
  • K562 Cells
  • Maianthemum / chemistry*
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Rhizome / chemistry*
  • Steroids* / chemistry
  • Steroids* / isolation & purification
  • Steroids* / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Steroids