Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086

Nat Prod Res. 2019 Feb;33(3):414-419. doi: 10.1080/14786419.2018.1455045. Epub 2018 Mar 30.

Abstract

A new polyene compound (1) and a new diketopiperazine (2), as well as three known compounds (3-5), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1-5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. These compounds were evaluated for their cytotoxic activities against K562 cell line and only compound 2 exhibited cytotoxicity against K562 cell, with IC50 value of 12.7 μM.

Keywords: Antarctic; Secondary metabolites; cytotoxicity; marine-derived fungus.

MeSH terms

  • Antarctic Regions
  • Aquatic Organisms
  • Diketopiperazines / chemistry
  • Diketopiperazines / isolation & purification*
  • Diketopiperazines / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • K562 Cells
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Penicillium / chemistry
  • Penicillium / metabolism*
  • Polyenes / chemistry
  • Polyenes / isolation & purification*
  • Polyenes / pharmacology

Substances

  • Diketopiperazines
  • Polyenes